Schizophrenia and bipolar disorder show both common and distinct changes in cortical interneuron markers

نویسندگان

  • Samantha J. Fung
  • Stu G. Fillman
  • Maree J. Webster
  • Cynthia Shannon Weickert
چکیده

Schizophrenia and bipolar disorder are often viewed as distinct clinical disorders, however there is substantial overlap in their neuropathologies. While compromised cortical interneurons are implicated in both diseases, few studies have examined the relative contribution of the distinct interneuron populations to each psychotic disorder. We report reductions in somatostatin and vasoactive intestinal peptide mRNAs in prefrontal and orbitofrontal cortices in bipolar disorder (n=31) and schizophrenia (n=35) compared to controls (n=34) and increased calbindin mRNA in schizophrenia. We show, at the molecular level, shared deficits in interneuron markers in schizophrenia and bipolar disorder, and a unique interneuron marker increase in schizophrenia.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Comparison of Sustained Attention and Cognitive Deficits in Patients with Schizophrenia and Bipolar Disorder Type II

Objective: The purpose of this study was to compare the sustained attention and cognitive deficits in patients with schizophrenia and bipolar disorder type II. Methods: The research method was causal-comparative (case-control) type. Statistical population was all the patients with bipolar disorder type II and schizophrenia at Isar and Fatemi hospitals in 2015 i...

متن کامل

The Comparison of Sustained Attention and Cognitive Deficits in Patients with Schizophrenia and Bipolar Disorder Type II

Objective: The purpose of this study was to compare the sustained attention and cognitive deficits in patients with schizophrenia and bipolar disorder type II. Methods: The research method was causal-comparative (case-control) type. Statistical population was all the patients with bipolar disorder type II and schizophrenia at Isar and Fatemi hospitals in 2015 i...

متن کامل

Association study of single nucleotide polymorphism rs165599 of COMT gene, with schizophrenia and bipolar mood disorder in the south-west of Iran

Linkage studies and epidemiological findings indicate that some possible genes in schizophrenia (SCZ) and bipolar mood disorder (BPD) are common. Numerous evidences for linkage of two diseases on chromosome 22 have been found. These findings suggest that one or more genes in the 22q11.21 region may be involved in the development of both disorders. In the present case-control study, association ...

متن کامل

Research Paper: Xerostomia in Schizophrenia and Bipolar Patients: Is There Any Relation?

Abstract Introduction: Psychiatric disorders such as bipolar disorder and schizophrenia cause vascular, neurological, and neurobiological changes. On other hand, salivary glands are influenced by changes in the autonomic nervous system. Therefore, this  hypothesis was formed that psychiatric disorders can affect salivary glands through neurological pathways. This study aimed to evaluate if sc...

متن کامل

بررسی اختلالات چربی خون و برخی عوامل مرتبط با آن در مبتلایان به اسکیزوفرنی و اختلال دو‌قطبی در شهرستان یزد

Introduction: Mortality rates in patients with schizophrenia and bipolar disorder are higher than the general population. Cardiovascular disease is the most important of natural cause of death in these patients. The aim of this study was to assess the prevalence of dyslipidemia and some of related factors in these patients. Methods: We conducted an analytic cross-sectional study on 200 subject...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Schizophrenia Research

دوره 155  شماره 

صفحات  -

تاریخ انتشار 2014